After a long search I found my answer: Yes, this is possible.I used this thread to find the solutions: http://forums.arcgis.com/threads/22818-Can-I-change-the-data-binding-for-a-FeatureDataGrid-in-code%E...Basically, I set my featuredatagrid.graphicslayer to equal the selected featurelayer within the combobox (I should also note that I did not need to set a Map binding for my featuredatagrid).Also, I had to make sure that the 'AutoGenerateColumns' option was set to true for my featuredatagrid to ensure my columns were displayed for each of the feature layers.