We recently installed ArcGIS Server 10.1. It was running fine, we could acces manager and the rest services. However out of the blue we began to recieve HTTP Error 404.0 not found when attempting to access manager or the rest directory. This occurs remotely and while logged into the server. I assumed it was the port 6080, however we have a specific rule for that and its working for other sites. I've checked .net and its running at 4.0, i've also re-installed server twice and it still is giving me the same 404 error.
Has anyone encounted a similar error and if so do you have any steps that I didnt mention above?
Also, we are running Windows server 2008 R2.