Hi!
We had the same issue.
My recommandation is to check if the port is blocked in the firewall.
1. First validate Data Store, if not verified:
2. Check if the server have access to the port 9220:
2.1 Go to ArcGIS DataStore server and Open PowerShell as administrator.
2.2 Type: tnc servername_including_domain -port 9220
2.3 If the response includes: tcpTestSucceeded : False => The firewall blocks the access for this port (9220).
3. Then, on the Data Store server, go to Windows Firewall with advanced security
4. Go to "Inbound rules"
5. Create "new inbound rule"
6. Choose:
a. Port: Yes
b. Allow the connection: Yes
c. Specific Ports: 9220
d. Give the rule a name, here: ArcGIS Spatial BigDataStore
e. Confirm and Save as new Rule
7. Open PowerShell and run the command again: “tnc dataStore_server_ip_incl_comain -port 9220
=> If TcpTestSucceeded: True, the access reestablished.
8. Go to ArcGIS Server Manager again > Site Data store > and verify donnection?