Yes, just about all our basemaps do contain building footprints at the larger map scales. But there is an option to customize one of our vector basemap styles using the Vector Tile Style Editor app to turn these features off. When you're logged in to ArcGIS Online you can either access the app directly, or you can access it through the Tile Layer in the Contents of your Map. I'll detail accessing the Editor through the Content of the Map.
Make sure your basemap gallery is showing Vector Maps. Navigation and Streets (Night) among others further down the list are only available as vector basemaps. You (your org admin) can set the default gallery to be vector maps.
I'm selecting the Navigation style street map for this example. In the map content, expand to see the layer for World Navigation Map and the little icon of the circle, square, and triangle. This opens the Vector Tile Style Editor. Rename your map style, add some tags and save it to your ArcGIS Content. This will be your custom map style. (I named my map: "Delete All Buildings")
You'll want to pick Edit Layer Styles icon from the far left menu tab. This allows you to select a feature layer in the map and make adjustments.
In the list of layer names, find the Buildings layer, select it, and make the change you want. You can change the colors of the building footprints, building shadows, building outline, etc. The "Visible" toggle switch can be flipped to turn all Building features off with one click.
The map will redraw on the fly. Buildings OFF ("Visible" switched off).
Other features can be controlled the same way. Change colors, line widths, font faces, font sizes, etc.
Click "Save Style and Close". This takes you back to the main map page in ArcGIS Online. You can use your customized vector basemap tile layer in web maps and apps. The web map you make can also be added to a group that is used in a custom basemap gallery.
This workflow shown was in ArcGIS Online, but can be replicated in ArcGIS Enterprise starting at version 10.8.x.