Chrome.... heard about it before causing disparate issues, I use Edge mostly or IE11 at worse
anti-virus? avg, kasp-somthing ... heard it before, similar thing, sometimes issues
firewall? at work I presume... you may not have the ability to deal with it
network? for data sources?
I never have had issues with windows 10, standalone, Mcafee, no firewall and definitely no network data or connections, on a high-end desktop. Same for laptop... Surface book ditto for everything else.
The home thing, suggests that it is the work environment and the things you may not have control over. Since I work in a large organization, there are the IT 'issues', however, we have the ability to say... no, do it this way... so we tend not to run into problems where IT dictates configurations downward, rather than needs driven upward.