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It could be a bad install. Uninstall and reinstall ArcGIS. Do a complete install and not a custom one.
Try renaming your ESRI folder in your registry:
Start Menu --> Run --> type "regedit" - Expand HKEY_CURRENT_USER folder - Expand Software folder within HKEY_CURRENT_USER - Rename the ESRI folder to ESRI_OLD
Had similar issue. Upon investigation it turned out that some folders under "C:\Program Files\ArcGIS\Desktop10.0\" (Including the 'ArcToolbox') were marked as HIDDEN in Windows, preventing ArcGIS application from seeing the contents. Right-clicked on the 'ArcToolbox' folder, opened Properties and unchecked the 'HIDDEN' parameter. After that the ArcToolbox got populated. Not sure how the folders became hidden in the first place...