Hi Mody,
I am starting to get that feeling.
Having some issues with artifacts, which I believe are being caused due to the lossy compression which causes the edges of the image to overlap with NoData areas and you see white 'rips' around the edges. Going back to the original tifs I see less issues. Having to shrink footprints a fair bit to get around the issue.
Looking around for any blogs or references to confirm advantages / disadvantages.
Cheers,
Mark