Creating a map series that will automatically create the scale of the map you need based on the map series index and clip based on that index feature without clipping labels that overrun the edge of the extent. If you have a layer you need labeled that happens to overrun the index boundary (like a 30 digit tax parcel ID), then it will not label. We need the ability to exclude labels like we do layers in the Map Properities>Clip Layers. However, the 'new center point' of the label would need to be what was coming from the clipped index and not the original center point of the feature polygon. Easier said then done I'm sure.
I realize there is a work around by using a "mask" layer. I could create what I need by doing an intersect, then a mask and excluding that layer in the series clip. But having to create a bunch of intersects and arbitrary data just to get labels to work is inefficient. Plus, the beauty of having a map series is when the underlying data in your SDE environment changes, you just refresh and export the new maps with ease. By having to use this "mask" work around you have to redo your intersects every time something changes. Converting to annotation won't work in a map series, as far as I know. And Label Properties>Position>Unplaced labels>Never remove does not work either as the clip seems to override it.