Hello Jason,
You have a few options. If you just want to work directly with the services themselves, the ArcGIS API for Python is part of Pro, and is a nice way to work with the data hosted over a REST endpoint: Using Feature Layers | ArcGIS for Developers
You also can call any GP tool from ArcPy, and then interact with the data as you would any other data with ArcPy. Both options work well, depending on what you're trying to do and what level of granularity you're working with.
Cheers,
Shaun